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Article

Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7.

Developmental cell - 1 Sept 2003

Shelly Maya, Mosesson Yaron, Citri Ami, Lavi Sara, Zwang Yaara, Melamed-Book Naomi, Aroeti Benjamin, Yarden Yosef

Abstract excerpt

ErbB-2/HER2 drives epithelial malignancies by forming heterodimers with growth factor receptors. The primordial invertebrate receptor is sorted to the basolateral epithelial surface by binding of the PDZ domain of Lin-7 to the receptor's tail. We show that all four human ErbBs are basolaterally expressed, even when the tail motif is absent. Mutagenesis of hLin-7 unveiled a second domain, KID, that binds to the...

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Identifiers

PMID: 12967566
DOI: 10.1016/j.devcel.2003.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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