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Article

Analysis of cancer mutations introduced into the Drosophila melanogaster Notch negative regulatory region uncovers a diversity of regulatory outcomes.

eLife - 4 Aug 2026

Shimizu Hideyuki, Baron Martin

Abstract excerpt

Activating mutations of Notch are drivers of the blood cell cancer, T-ALL, and some solid tumours. The negative regulatory region (NRR) of the extracellular domain (ECD) and the PEST region of the intracellular domain (ICD) are mutation hot spots which can act synergistically in T-ALL. The NRR, comprised of a heterodimerisation domain (HD) and three Lin12/Notch repeats (LNR A-C), masks the S2 cleavage site,...

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Identifiers

PMID: 42550591
DOI: 10.7554/eLife.108812
PMCID: PMC13436963

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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