Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.

Protein science : a publication of the Protein Society - 1 Feb 2020

Teyra Joan, Ernst Andreas, Singer Alex, Sicheri Frank, Sidhu Sachdev S

Abstract excerpt

To understand the molecular evolution of functional diversity in protein families, we comprehensively investigated the consequences of all possible mutation combinations separating two peptide-binding domains with highly divergent specificities. We analyzed the Erbin PDZ domain (Erbin-PDZ), which exhibits canonical type I specificity, and a synthetic Erbin-PDZ variant (E-14) that differs at six positions and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to LIM Domain Proteins

Share to Models, Molecular

Share to Mutation

Share to PDZ Domains

Share to Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 31654425
DOI: 10.1002/pro.3759
PMCID: PMC6954693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.PMID 31654425Read ↗

A specificity map for the PDZ domain family.Semantic proximity Read ↗

Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution.Semantic proximity Read ↗

Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.Semantic proximity Read ↗

Computer-aided design of a PDZ domain to recognize new target sequences.Semantic proximity Read ↗

Characterizing Class I WW domains defines key specificity determinants and generates mutant domains with novel specificities.Semantic proximity Read ↗

Insights into the Molecular Evolution of the PDZ/LIM Family and Identification of a Novel Conserved Protein MotifSemantic proximity Read ↗

Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?Semantic proximity Read ↗

Inferring PDZ domain multi-mutant binding preferences from single-mutant data.Semantic proximity Read ↗

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targetsSemantic proximity Read ↗

Allosteric and energetic remodeling of a PDZ domain by protein domain extensions.Semantic proximity Read ↗

Domain structure and transcript diversity of plectin.Semantic proximity Read ↗

Proteome-wide analysis of phospho-regulated PDZ domain interactions through phosphomimetic proteomic peptide phage displaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.