Article
[Adenine phosphoribosyltransferase (APRT)].
Nihon rinsho. Japanese journal of clinical medicine - 1 Dec 1996
Kamatani N
Abstract excerpt
Adenine phosphoribosyltransferase (APRT) is a purine metabolic enzyme that salvages adenine moiety generated via the polyamine synthetic pathway. Adenine is produced by the cleavage of methylthiodenosine (MTA), a by-product of the polyamine synthesis. None of the normal somatic cells but about 23% of human malignant cells lack the enzyme MTA phosphorylase because of the homozygous deletion of 9p21 and are...
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