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Article

Mutational analysis of the structure and function of the adenine phosphoribosyltransferase enzyme of Chinese hamster.

Journal of molecular biology - 5 Sept 1991

de Boer J G, Glickman B W

Abstract excerpt

We have analyzed the adenine phosphoribosyltransferase (APRT) enzyme from Chinese hamster ovary cells through the study of mutants that are able to grow in the presence of the toxic adenine analogue 8-azaadenine. The distribution of the amino acid alterations was analyzed in terms of the binding regions for the purine and phosphoribosylpyrophosphate substrates and a comparison was made with mutants known in human...

Topics

Adenine Phosphoribosyltransferase
Amino Acid Sequence
Animals
Binding Sites
Cell Line
Cricetinae
DNA Mutational Analysis
Molecular Sequence Data
Mutation
Phosphoribosyl Pyrophosphate
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Alignment

Structure-Activity Relationship

Source

Identifiers

PMID: 1717694
DOI: 10.1016/0022-2836(91)80212-d

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717694-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutational analysis of the structure and function of the adenine phosphoribosyltransferase enzyme of Chinese hamster.PMID 1717694Read ↗

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