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Article

A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.

Genetics - 1 Jun 2011

Holland Catherine, Lipsett David B, Clark Denise V

Abstract excerpt

The biosynthetic pathways and multiple functions of purine nucleotides are well known. However, the pathways that respond to alterations in purine nucleotide synthesis in vivo in an animal model organism have not been identified. We examined the effects of inhibiting purine de novo synthesis in vivo and in cultured cells of Drosophila melanogaster. The purine de novo synthesis gene ade2 encodes...

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Identifiers

PMID: 21441212
DOI: 10.1534/genetics.110.124222
PMCID: PMC3122316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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