Article
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 1998
Oliver P M, John S W, Purdy K E, Kim R, Maeda N, Goy M F, Smithies O
Abstract excerpt
Activation of the natriuretic peptide system lowers blood pressure and causes the excretion of salt. Atrial natriuretic peptide and B-type natriuretic peptide are the humoral mediators of this effect; they act primarily by binding to membrane-bound natriuretic peptide receptor A (NPRA) and stimulating its intrinsic guanylate cyclase activity. To study whether genetically determined differences in NPRA expression...
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