Article
The angiotensin II receptor (Agtr1a): functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse.
Physiological genomics - 24 Jun 2003
Wong Clifford, Mahapatra Nitish R, Chitbangonsyn Surin, Mahboubi Payam, Mahata Manjula, Mahata Sushil K, O'Connor Daniel T
Abstract excerpt
Hypertension is a complex trait with multiple genetic determinants. A previous genome-wide linkage study of systolic blood pressure in a mouse genetic backcross implicated a region of chromosome 13 (LOD = 3.3 at 16.0 cM) as a determinant of blood pressure differences between a hereditary low blood pressure strain of Mus musculus (BPL/1) and Mus spretus (SPRET); at this locus, the unexpected effect of the BPL/1...
Topics
- Angiotensin II
- Animals
- Blood Pressure
- Cell Line
- Chromaffin Cells
- Conserved Sequence
- Exons
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Introns
- Male
- Mice
- Mice, Inbred C57BL