Article
Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese.
Pharmacogenetics - 1 Aug 1994
Stephens E A, Taylor J A, Kaplan N, Yang C H, Hsieh L L, Lucier G W, Bell D A
Abstract excerpt
Human cytochrome P4502E1 (CYP2E1) is inducible by ethanol and is involved in metabolism of many known carcinogens including N-nitrosodimethylamine, butadiene, benzene, and carbon tetrachloride. A 50-fold variability in CYP2E1 enzyme activity in humans has been observed but it is unknown whether t...
Topics
- Asian People
- Black People
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- DNA Primers
- Deoxyribonucleases, Type II Site-Specific
- Europe
- Genotype
- Haplotypes
- Humans
- Molecular Sequence Data
- Oxidoreductases, N-Demethylating