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Article

Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse.

Alcoholism, clinical and experimental research - 1 Aug 2001

Walker S J, Grant K A, Vrana K E

Abstract excerpt

BACKGROUND: Cytochrome P-450 2E1 (CYP2E1) is involved in alcohol metabolism, and the expression of this enzyme displays wide phenotypic variability in humans. It has been proposed that some of this variability in expression may be a consequence of the size of a repeat polymorphism in the 5" regulatory region of the gene and that the polymorphism may segregate with alcoholism. This study examined whether the...

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PMID: 11505041

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