Article
Cutting Edge: Multiple autoimmune pathways in kd/kd mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2003
Hancock Wayne W, Tsai Tsai-Lung, Madaio Michael P, Gasser David L
Abstract excerpt
The kidney disease (kd) mutation was transferred to a C57BL/6 (B6) background by selection for closely linked microsatellite markers. The resulting congenic strain, B6.kd, was mated with partners homozygous for targeted mutations of CD4, CD8, CD28, IL-2, recombinase-activating gene-1 (Rag-1), ICAM-1, or beta(2)-microglobulin. In most of the resulting double mutants, kidney disease occurred as readily and as...
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