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Article

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2003

Jacob Chaim O, Zang Song, Li Lily, Ciobanu Voicu, Quismorio Frank, Mizutani Akiei, Satoh Minoru, Koss Michael

Abstract excerpt

We have developed novel genetically lupus-prone (NZB x NZW)F(1)-derived congenic New Zealand mixed (NZM) 2328 lines, which are either Stat4- or Stat6-deficient. Our studies show that the deficiency of Stat4 and Stat6 significantly alters the phenotype of the lupus-like disease in NZM 2328 congenic mice. Specifically, Stat4-deficient NZM mice develop accelerated nephritis and increased mortality in the absence of...

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PMID: 12874250
DOI: 10.4049/jimmunol.171.3.1564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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