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Article

Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2013

Xu Miduo, Hou Rong, Sato-Hayashizaki Aya, Man Rongyong, Zhu Chenghua, Wakabayashi Chisato, Hirose Sachiko, Adachi Takahiro, Tsubata Takeshi

Abstract excerpt

Although modifier genes are extensively studied in various diseases, little is known about modifier genes that regulate autoimmune diseases. Autoimmune disease caused by the Fas(lpr) mutation depends on the genetic background of mouse strains, suggesting a crucial role of modifier genes. MRL/MpJ-Fas(lpr) (MRL/lpr) and AKR/lpr mice develop severe and mild lupus-like autoimmune disease, respectively, whereas this...

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PMID: 23616572
DOI: 10.4049/jimmunol.1203576

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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