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Article

Strain- and Diet-Related Lesion Variability in Aging DBA/2, C57BL/6, and DBA/2xC57BL/6 F1 Mice.

Veterinary pathology - 1 Mar 2016

Harbison C E, Lipman R D, Bronson R T

Abstract excerpt

Genetic and environmental factors both play a role in the occurrence of age-related disease. To examine the genetic contribution to the development of spontaneous lesions in aging animals, a complete range of tissues was comprehensively analyzed by histopathology from 180 individually housed ad libitum-fed or 40% calorically restricted 24-month-old male and female mice of 2 parental strains-DBA/2NNia (D2) and...

Topics

Aging
Animals
Caloric Restriction
Diet
Disease Models, Animal
Female
Gene-Environment Interaction
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Phenotype

Species Specificity

Source

Identifiers

PMID: 26604215
DOI: 10.1177/0300985815612152

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