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Article

BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2004

Buckley S, Shi W, Driscoll B, Ferrario A, Anderson K, Warburton D

Abstract excerpt

Lung cancer is the most common visceral malignancy in males, with rapidly increasing incidence in females, and a devastatingly poor prognosis. Transforming growth factor (TGF)-beta has been shown to induce senescence in A549 lung cancer cells, and both TGF-beta and bone morphogenetic protein (BMP) 2 can suppress the transformed phenotype of A549 cells in vitro. We examined the effects of BMP4, another member of...

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Identifiers

PMID: 12959928
DOI: 10.1152/ajplung.00160.2003

Genes

BMP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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