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Article

Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway.

Genes - 2 Sept 2022

Li Hao, Qiu Lei, Liu Qing, Ma Zelong, Xie Xiaoli, Luo Ying, Wu Xiaoming

Abstract excerpt

Aging has been recently reported to promote lung cancer initiation and progression. Senescent fibroblasts gain a cancer-associated fibroblast (CAF) phenotype, and exert a powerful influence on cancer behavior, such as tumor cell growth and metastasis. However, mechanisms linking fibroblast senescence with CAF activation remain poorly understood. Our study shows that senescent fibroblasts displayed CAF properties,...

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Identifiers

PMID: 36140747
DOI: 10.3390/genes13091579
PMCID: PMC9498467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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