Article
Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer
2 Mar 2015
Abstract excerpt
Cellular senescence is an initial barrier for carcinogenesis. However, the signaling mechanisms that trigger cellular senescence are incompletely understood, particularly in vivo. Here we identify Wnt7a as a novel upstream inducer of cellular senescence. In two different mouse strains (C57Bl/6J and FVB/NJ), we show that the loss of Wnt7a is a major contributing factor for increased lung tumorigenesis owing to...
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