Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of v-ErbA with Smad4 disrupts TGF-beta signaling.

Molecular biology of the cell - 1 Mar 2009

Erickson Richard A, Liu Xuedong

Abstract excerpt

Disruption of the transforming growth factor-beta (TGF-beta) pathway is observed in the majority of cancers. To further understand TGF-beta pathway inactivation in cancer, we stably expressed the v-ErbA oncoprotein in TGF-beta responsive cells. v-ErbA participates in erythroleukemic transformation of cells induced by the avian erythroblastosis virus (AEV). Here we demonstrate that expression of v-ErbA was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Cell Line
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Erythroblasts

Share to Signal Transduction

Share to Smad4 Protein

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 19144825
DOI: 10.1091/mbc.e08-08-0836
PMCID: PMC2649266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of v-ErbA with Smad4 disrupts TGF-beta signaling.PMID 19144825Read ↗

v-erbA acts on retinoic acid receptors in immature avian erythroid cells.Semantic proximity Read ↗

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.Semantic proximity Read ↗

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-β signaling by inactivating the TGF-β type II receptorSemantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3Semantic proximity Read ↗

ELL Protein-associated Factor 2 (EAF2) Inhibits Transforming Growth Factor β Signaling through a Direct Interaction with Smad3Semantic proximity Read ↗

Multiple mutations contribute to repression by the v-Erb A oncoprotein.Semantic proximity Read ↗

Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.Semantic proximity Read ↗

Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate CancerSemantic proximity Read ↗

Transformation of murine pre-B-lymphocytes by v-erb-B: progression to growth factor independence and tumorigenicity.Semantic proximity Read ↗

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.Semantic proximity Read ↗

The PDZ protein erbin modulates beta-catenin-dependent transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.