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Article

Invasion and metastasis of a mammary tumor involves TGF-beta signaling.

International journal of cancer - 1 Jan 2001

McEarchern J A, Kobie J J, Mack V, Wu R S, Meade-Tollin L, Arteaga C L, Dumont N, Besselsen D, Seftor E, Hendrix M J, Katsanis E, Akporiaye E T

Abstract excerpt

Several studies have correlated escape from TGF-beta-mediated cell cycle arrest with the tumorigenic phenotype. Most often, this escape from growth control has been linked to dysfunctional TGF-beta receptors or defects in the TGF-beta-mediated SMAD signaling pathway. In this report, we found that highly metastatic 4T1 mammary carcinoma cells express functional TGF-beta receptors capable of initiating...

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Source

Identifiers

PMID: 11149423
DOI: 10.1002/1097-0215(20010101)91:1<76::aid-ijc1012>3.0.co;2-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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