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Article

E2A selectively regulates TGF-β-induced apoptosis in KRAS-mutant non-small cell lung cancer.

Molecular oncology - 1 Jul 2026

Chuikov Sergei, Katkam Shiva Krishna, Wang Zhefan, Keshamouni Venkateshwar G

Abstract excerpt

Transforming growth factor-β (TGF-β) regulates epithelial homeostasis by inducing growth arrest and apoptosis during early carcinogenesis; however, these tumor-suppressive functions are frequently lost in advanced nonsmall cell lung cancer (NSCLC) despite intact signaling. We identify the transcription factor E2A as a critical mediator of resistance to TGF-β-induced apoptosis in mutant KRAS-driven NSCLC. TGF-β...

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Topics

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Share to Apoptosis
Share to Carcinoma, Non-Small-Cell Lung
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Lung Neoplasms

Share to Mutation

Share to Proto-Oncogene Proteins p21(ras)

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 41841523
DOI: 10.1002/1878-0261.70236
PMCID: PMC13352951

Genes

KRAS
SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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