Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of PTTG (Pituitary Tumor Transforming Gene) in Esophageal Cancer

1 Jul 2002

Abstract excerpt

BACKGROUND: Recently, a vertebrate securin [pituitary tumor transforming gene (PTTG) in humans] has been identified that inhibits sister chromatid separation and is involved in malignant transformation and tumorigenesis. Abundance of this protein would disrupt cell division, generate chromosomal instability and thereby increase cell susceptibility to acquisition of further mutations during subsequent division....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Neuroendocrine Tumor Research Advances
Share to Pituitary Gland Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12324572
DOI: 10.1093/jjco/hyf058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of PTTG (Pituitary Tumor Transforming Gene) in Esophageal CancerPMID 12324572Read ↗

Increased expression of pituitary tumor-transforming gene (PTTG)-1 is correlated with poor prognosis in glioma patientsSemantic proximity Read ↗

Pituitary tumor-transforming gene and its binding factor in endocrine cancerSemantic proximity Read ↗

Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells.Semantic proximity Read ↗

Pituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectivesSemantic proximity Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor Through Activation of MMP-2.Semantic proximity Read ↗

Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts.Semantic proximity Read ↗

Pituitary Tumor Transforming Gene (PTTG) Regulates Placental JEG-3 Cell Division and Survival: Evidence from Live Cell ImagingSemantic proximity Read ↗

Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells.Semantic proximity Read ↗

Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivoSemantic proximity Read ↗

Protein stabilization by RSUME accounts for PTTG pituitary tumor abundance and oncogenicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.