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Article

PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro.

Journal of molecular endocrinology - 1 Dec 2004

Boelaert K, Yu R, Tannahill L A, Stratford A L, Khanim F L, Eggo M C, Moore J S, Young L S, Gittoes N J L, Franklyn J A, Melmed S, McCabe C J

Abstract excerpt

Human pituitary tumor-transforming gene (PTTG), known also as securin, is a multifunctional protein implicated in the control of mitosis and the pathogenesis of thyroid, colon, oesophageal and other tumour types. Critical to PTTG function is a C-terminal double PXXP motif, forming a putative SH3-interacting domain and housing the gene's sole reported phosphorylation site. The exact role of phosphorylation and...

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Identifiers

PMID: 15591026
DOI: 10.1677/jme.1.01606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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