Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pituitary tumor-transforming gene and its binding factor in endocrine cancer

1 Dec 2010

Abstract excerpt

The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG) that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian carcinomas. PTTG induces cellular transformation in vitro and tumourigenesis in vivo, and several mechanisms by which PTTG contributes to tumourigenesis have been investigated. Also known as the human securin, PTTG is involved in cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Microtubule and mitosis dynamics
Share to Pituitary Gland Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21129230
DOI: 10.1017/s1462399410001699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pituitary tumor-transforming gene and its binding factor in endocrine cancerPMID 21129230Read ↗

Increased expression of pituitary tumor-transforming gene (PTTG)-1 is correlated with poor prognosis in glioma patientsSemantic proximity Read ↗

Pituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectivesSemantic proximity Read ↗

Expression of PTTG (Pituitary Tumor Transforming Gene) in Esophageal CancerSemantic proximity Read ↗

Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor Through Activation of MMP-2.Semantic proximity Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Pituitary Tumor Transforming Gene (PTTG) Regulates Placental JEG-3 Cell Division and Survival: Evidence from Live Cell ImagingSemantic proximity Read ↗

Pituitary tumour transforming gene: a novel factor in pituitary tumour formation.Semantic proximity Read ↗

SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human SeminomaSemantic proximity Read ↗

Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells.Semantic proximity Read ↗

PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro.Semantic proximity Read ↗

Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.