Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Design and characterization of an HIV-1 Tat mutant: inactivation of viral and cellular functions but not antigenicity.

Vaccine - 10 Aug 2007

Mayol Katia, Munier Séverine, Beck Alain, Verrier Bernard, Guillon Christophe

Abstract excerpt

Among HIV-1 proteins, Tat is a promising antigen for consideration as a component of anti-HIV-1 vaccine formulations. Nevertheless, this viral protein is able to affect the expression of several cellular genes that are implicated in immune response. In this study, we designed and characterized a mutant form of Tat ("STLA Tat"), which is unable to transactivate viral transcription, and which has lost the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to Cell Line
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, tat

Share to Histocompatibility Antigens Class I

Share to HIV Antigens

Share to Interleukin-2

Share to Interleukin-2 Receptor alpha Subunit

Source

Identifiers

PMID: 17604883
DOI: 10.1016/j.vaccine.2007.05.048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Design and characterization of an HIV-1 Tat mutant: inactivation of viral and cellular functions but not antigenicity.PMID 17604883Read ↗

HIV-1 Tat protein as a potential AIDS vaccine.Semantic proximity Read ↗

Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency.Semantic proximity Read ↗

Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and PathogenesisSemantic proximity Read ↗

Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat proteinSemantic proximity Read ↗

Tat mutations in an African cohort that do not prevent transactivation but change its immunogenic properties.Semantic proximity Read ↗

Characterization of HIV-1 Tat proteins mutated in the transactivation domain for prophylactic and therapeutic application.Semantic proximity Read ↗

Tits and bits of HIV Tat protein.Semantic proximity Read ↗

Functions of Tat: the versatile protein of human immunodeficiency virus type 1Semantic proximity Read ↗

Tat is a multifunctional viral protein that modulates cellular gene expression and functionsSemantic proximity Read ↗

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.Semantic proximity Read ↗

Preferential expression and immunogenicity of HIV-1 Tat fusion protein expressed in tomato plant.Semantic proximity Read ↗

Procedures for preparing biologically inactive, but immunogenic HIV-1 Tat protein (Tat toxoid) for human use.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.