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Article

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia.

Journal of neurovirology - 1 Feb 2011

Cowley Daniel, Gray Lachlan R, Wesselingh Steven L, Gorry Paul R, Churchill Melissa J

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) demonstrates a high degree of viral diversity which has an impact on viral fitness. Genetic compartmentalization of HIV-1 proteins between central nervous system (CNS) and lymphoid tissues is well established and reflects altered requirements for HIV-1 replication in macrophages/microglia, brain-specific immune selection pressures and possibly the timing of virus...

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Share to AIDS Dementia Complex
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to tat Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 21165788
DOI: 10.1007/s13365-010-0002-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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