Article
tat Exon 1 exhibits functional diversity during HIV-1 subtype C primary infection.
Journal of virology - 1 May 2013
Rossenkhan Raabya, MacLeod Iain J, Sebunya Theresa K, Castro-Nallar Eduardo, McLane Mary Fran, Musonda Rosemary, Gashe Berhanu A, Novitsky Vlad, Essex M
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) Tat is a mediator of viral transcription and is involved in the control of virus replication. However, associations between HIV-1 Tat diversity and functional effects during primary HIV-1 infection are still unclear. We estimated selection pressures in tat exon 1 using the mixed-effects model of evolution with 672 viral sequences generated from 20 patients infected with...
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