Genetic Characterization of HIV-1 tat Gene from Virologically Controlled Aging Individuals with HIV on Long-Term Antiretroviral Therapy.

doi:10.1089/aid.2024.0029

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Genetic Characterization of HIV-1 tat Gene from Virologically Controlled Aging Individuals with HIV on Long-Term Antiretroviral Therapy.

AIDS research and human retroviruses - 1 Mar 2025

Kummet Nathan, Mishra Neha, Diaz Adela, Cusick Nicholas, Klotz Stephen, Ahmad Nafees

Abstract excerpt

Despite advancements in antiretroviral therapy (ART) that reduces the viral load to undetectable levels and improve CD4 T cell counts, viral eradication has not been achieved due to HIV-1 persistence in resting CD4+ T-cells. We, therefore, characterized the tat gene, which is essential for HIV-1 replication and pathogenesis, from 20 virologically controlled aging individuals with HIV (HIV+) on long-term ART and...

Topics

Humans
HIV Infections
HIV-1
Phylogeny
Middle Aged
Male
Female
tat Gene Products, Human Immunodeficiency Virus
Aged
CD4 Lymphocyte Count
Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Sequence Analysis, DNA

Adult

Anti-Retroviral Agents

Viral Load

CD4-Positive T-Lymphocytes

Anti-HIV Agents

Source

Open in PubMed

Identifiers

PMID: 39723946
DOI: 10.1089/aid.2024.0029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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