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Article

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells.

Retrovirology - 17 Apr 2014

Kukkonen Sami, Martinez-Viedma Maria Del Pilar, Kim Nayoung, Manrique Mariana, Aldovini Anna

Abstract excerpt

BACKGROUND: We have shown that HIV-1 Tat interaction with MAP2K3, MAP2K6, and IRF7 promoters is key to IFN-stimulated genes (ISG) activation in immature dendritic cells and macrophages. RESULTS: We evaluated how Tat alleles and mutants differ in cellular gene modulation of immature dendritic cells and monocyte-derived macrophages and what similarities this modulation has with that induced by interferons. The...

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Share to Antigen-Presenting Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

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Share to tat Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 24742347
DOI: 10.1186/1742-4690-11-30
PMCID: PMC4036831

Genes

CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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