ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.

doi:10.1200/JCO.2003.10.130

Article

ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2003

Garcia-Rostan Ginesa, Zhao Hongyu, Camp Robert L, Pollan Marina, Herrero Agustin, Pardo Javier, Wu Ran, Carcangiu Maria Luisa, Costa Jose, Tallini Giovanni

Abstract excerpt

PURPOSE: ras oncogenic activation has long been demonstrated in thyroid carcinomas of follicular cell derivation, but no consistent relationship has been shown between mutations and clinicopathologic features. MATERIALS AND METHODS: We analyzed H-, K-, and N-ras mutations by polymerase chain reaction-single-strand conformational polymorphism followed by DNA sequencing in 125 thyroid carcinoma specimens from 107...

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ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.

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ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.

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