Article
Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations.
Thyroid : official journal of the American Thyroid Association - 1 Jan 2021
Hernandez-Prera Juan C, Valderrabano Pablo, Creed Jordan H, de la Iglesia Janis V, Slebos Robbert J C, Centeno Barbara A, Tarasova Valentina, Hallanger-Johnson Julie, Veloski Colleen, Otto Kristen J, Wenig Bruce M, Yoder Sean J, Lam Cesar A, Park Derek S, Anderson Alexander R, Raghunand Natarajan, Berglund Anders, Caudell Jimmy, Gerke Travis A, Chung Christine H
Abstract excerpt
Background:RAS gene family mutations are the most prevalent in thyroid nodules with indeterminate cytology and are present in a wide spectrum of histological diagnoses. We evaluated differentially expressed genes and signaling pathways across the histological/clinical spectrum of RAS-mutant nodules to determine key molecular determinants associated with a high risk of malignancy. Methods: Sixty-one thyroid...
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