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Article

Additional Oncogenic Alterations in RAS-Driven Differentiated Thyroid Cancers Associate with Worse Clinicopathologic Outcomes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Jul 2023

Bikas Athanasios, Ahmadi Sara, Pappa Theodora, Marqusee Ellen, Wong Kristine, Nehs Matthew A, Cho Nancy L, Haase Jacob, Doherty Gerard M, Sehgal Kartik, Barletta Justine A, Alexander Erik K, Landa Iñigo

Abstract excerpt

PURPOSE: RAS mutations occur across the spectrum of thyroid neoplasms, and more tools are needed for better prognostication. The objective of this study was to evaluate how additional genetic events affecting key genes modify prognosis in patients with RAS-mutant thyroid cancers, and specifically differentiated thyroid cancers (DTC). EXPERIMENTAL DESIGN: We performed a clinical-genomic analysis of consecutive...

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Source

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Identifiers

PMID: 37260297
DOI: 10.1158/1078-0432.CCR-23-0278
PMCID: PMC10524472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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