Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence.

doi:10.1158/1078-0432.CCR-17-1183

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Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2017

Ibrahimpasic Tihana, Xu Bin, Landa Iñigo, Dogan Snjezana, Middha Sumit, Seshan Venkatraman, Deraje Shyam, Carlson Diane L, Migliacci Jocelyn, Knauf Jeffrey A, Untch Brian, Berger Michael F, Morris Luc, Tuttle R Michael, Chan Timothy, Fagin James A, Ghossein Ronald, Ganly Ian

Abstract excerpt

Purpose: Patients with anaplastic thyroid cancer (ATC) have a very high death rate. In contrast, deaths from non-anaplastic thyroid (NAT) cancer are much less common. The genetic alterations in fatal NAT cancers have not been reported.Experimental Design: We performed next-generation sequencing of 410 cancer genes from 57 fatal NAT primary cancers. Results were compared with The Cancer Genome Atlas study (TCGA...

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Identifiers

PMID: 28634282
DOI: 10.1158/1078-0432.CCR-17-1183
PMCID: PMC5626586

Genes

BRAF
MED12
RBM10
TERT
DLG5
POLE
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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