Prevalence of activating ras mutations in morphologically characterized thyroid nodules.

doi:10.1089/thy.1996.6.409

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Article

Prevalence of activating ras mutations in morphologically characterized thyroid nodules.

Thyroid : official journal of the American Thyroid Association - 1 Oct 1996

Ezzat S, Zheng L, Kolenda J, Safarian A, Freeman J L, Asa S L

Abstract excerpt

Ras proteins are signal-transducing proteins that share common properties with membrane-anchored G proteins. Mutations at codon 12/13 or codon 61 alter GTP-binding or GTPase activity, respectively. Such activating mutations are present in nearly 30-50% of various malignancies including colon, breast, and lung carcinomas. There are conflicting data regarding the prevalence of ras mutations in the thyroid and their...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Codon
DNA
DNA Primers
DNA, Neoplasm
Female
Genes, ras
Humans
Male
Middle Aged
Mutation
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 8936664
DOI: 10.1089/thy.1996.6.409

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