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Article

Prevalence of activating ras mutations in morphologically characterized thyroid nodules.

Thyroid : official journal of the American Thyroid Association - 1 Oct 1996

Ezzat S, Zheng L, Kolenda J, Safarian A, Freeman J L, Asa S L

Abstract excerpt

Ras proteins are signal-transducing proteins that share common properties with membrane-anchored G proteins. Mutations at codon 12/13 or codon 61 alter GTP-binding or GTPase activity, respectively. Such activating mutations are present in nearly 30-50% of various malignancies including colon, breast, and lung carcinomas. There are conflicting data regarding the prevalence of ras mutations in the thyroid and their...

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PMID: 8936664
DOI: 10.1089/thy.1996.6.409

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