Article
Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics.
Cancer cytopathology - 1 Dec 2014
Radkay Lisa A, Chiosea Simion I, Seethala Raja R, Hodak Steven P, LeBeau Shane O, Yip Linwah, McCoy Kelly L, Carty Sally E, Schoedel Karen E, Nikiforova Marina N, Nikiforov Yuri E, Ohori N Paul
Abstract excerpt
BACKGROUND: Mutations in the RAS gene in the thyroid gland result in the activation of signaling pathways and are associated with a follicular growth pattern and the probability of a carcinoma outcome ranging from 74% to 87%. In the current study, the authors investigated the cytopathologic and histopathologic features of common RAS mutation subtypes. METHODS: Malignant, indeterminate, and selected benign thyroid...
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