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Article

The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

Molecular biology of the cell - 1 Nov 2013

Ivanova Tsvetomira, Alves-Rodrigues Isabel, Gómez-Escoda Blanca, Dutta Chaitali, DeCaprio James A, Rhind Nick, Hidalgo Elena, Ayté José

Abstract excerpt

In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by Cds1, resulting in activation of MluI-binding factor (MBF)-dependent transcription. This is essential to reinitiate DNA synthesis and for correct G1-to-S transition. Here we show that Cdc10, which...

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Identifiers

PMID: 24006488
DOI: 10.1091/mbc.E13-05-0257
PMCID: PMC3814153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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