Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors.

The Journal of biological chemistry - 14 Nov 2003

Cheng Su-Li, Shao Jian-Su, Charlton-Kachigian Nichole, Loewy Arleen P, Towler Dwight A

Abstract excerpt

In the aorta, diabetes activates an osteogenic program that includes expression of bone morphogenetic protein-2 (BMP2) and the osteoblast homeoprotein Msx2. To evaluate BMP2-Msx2 signaling in vascular calcification, we studied primary aortic myofibroblasts. These cells express vascular smooth mus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Alkaline Phosphatase
Share to Aorta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesoderm

Share to Mice, Inbred C3H

Share to Myocytes, Smooth Muscle

Share to Receptors, Cytoplasmic and Nuclear

Share to Retroviridae

Source

Identifiers

PMID: 12925529
DOI: 10.1074/jbc.M306972200

Genes

BMP2
MSX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12925529-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors.PMID 12925529Read ↗

Msx2 is required for vascular smooth muscle cells osteoblastic differentiation but not calcification in insulin-resistant ob/ob mice.Semantic proximity Read ↗

Bone Morphogenetic Protein-Induced Msx1 and Msx2 Inhibit Myocardin-Dependent Smooth Muscle Gene TranscriptionSemantic proximity Read ↗

KAP1 modulates osteogenic differentiation via the ERK/Runx2 cascade in vascular smooth muscle cellsSemantic proximity Read ↗

Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2.Semantic proximity Read ↗

Arterial Calcification in Diabetes Mellitus: Preclinical Models and Translational Implications.Semantic proximity Read ↗

Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells.Semantic proximity Read ↗

An ncBAF-ETS2 Chromatin-Remodelling Axis Drives Vascular Smooth Muscle Cell Osteogenic Reprogramming in Vascular CalcificationSemantic proximity Read ↗

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineagesSemantic proximity Read ↗

The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.Semantic proximity Read ↗

Nesfatin-1 mitigates calcific aortic valve disease via suppressing ferroptosis mediated by GSH/GPX4 and ZIP8/SOD2 axesSemantic proximity Read ↗

Cell Phenotype Transitions in Cardiovascular CalcificationSemantic proximity Read ↗

NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.