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Article

Msx2 is required for vascular smooth muscle cells osteoblastic differentiation but not calcification in insulin-resistant ob/ob mice.

Atherosclerosis - 1 Oct 2017

Andrade Maria Claudina, Carmo Luciana S, Farias-Silva Elisangela, Liberman Marcel

Abstract excerpt

BACKGROUND AND AIMS: Obesity and diabetes potentiate vascular calcification by increasing vascular smooth muscle cells osteoblastic differentiation mediated by the transcription factor Msx2 and bone morphogenetic protein-2 signaling. However, Bmp-2/Msx2 crosstalk to induce VSMC osteogenic phenotype transition and calcification is poorly understood in diabetes. We aimed to investigate mechanisms underlying...

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Identifiers

PMID: 28829997
DOI: 10.1016/j.atherosclerosis.2017.07.028

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