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Article

The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.

PloS one - 1 Jan 2011

Zhu Dongxing, Mackenzie Neil Charles Wallace, Millán José Luis, Farquharson Colin, MacRae Vicky Elizabeth

Abstract excerpt

BACKGROUND: Vascular calcification is an indicator of elevated cardiovascular risk. Vascular smooth muscle cells (VSMCs), the predominant cell type involved in medial vascular calcification, can undergo phenotypic transition to both osteoblastic and chondrocytic cells within a calcifying environment. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, using in vitro VSMC calcification studies in conjunction...

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Identifiers

PMID: 21611184
DOI: 10.1371/journal.pone.0019595
PMCID: PMC3096630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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