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Article

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

22 Jul 2021

Abstract excerpt

Abstract Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is controlled by the Tie2 promoter. Tie2CRE/+;Bmp2tg/tg mice develop aortic valve dysfunction postnatally, accompanied by pre-calcific lesion formation in valve...

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PMID: 34294700
DOI: 10.1038/s41419-021-04003-0

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