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Article

Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2.

Experimental & molecular medicine - 1 Nov 2021

Kwon Duk-Hwa, Choe Nakwon, Shin Sera, Ryu Juhee, Kim Nacksung, Eom Gwang Hyeon, Nam Kwang-Il, Kim Hyung Seok, Ahn Youngkeun, Kim Young-Kook, Park Woo Jin, Mendrysa Susan M, Kook Hyun

Abstract excerpt

Vascular calcification increases morbidity and mortality in patients with cardiovascular and renal diseases. Previously, we reported that histone deacetylase 1 prevents vascular calcification, whereas its E3 ligase, mouse double minute 2 homolog (MDM2), induces vascular calcification. In the present study, we identified the upstream regulator of MDM2. By utilizing cellular models and transgenic mice, we confirmed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34845330
DOI: 10.1038/s12276-021-00708-6
PMCID: PMC8639964

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