Article

KAP1 modulates osteogenic differentiation via the ERK/Runx2 cascade in vascular smooth muscle cells

2022-11-17

Abstract excerpt

<h4>Background: </h4> Osteoblast phenotypic transition in vascular smooth muscle cells (VSMCs) has been unveiled as a common cause of vascular calcification (VC). Krüppel-Associated Box (KRAB)-Associated Protein 1(KAP1) is a transcriptional corepressor that modulates various intracellular pathological processes from gene expression to DNA repair to signal transduction. However, the function and mechanism of KAP1 o...

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Literature Corpus work: 2e71b366-1bb6-5e14-bf09-67e08288b4d1
DOI: 10.21203/rs.3.rs-2251112/v1

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