Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2013

Cheng Su-Li, Shao Jian-Su, Behrmann Abraham, Krchma Karen, Towler Dwight A

Abstract excerpt

OBJECTIVE: Endothelial cells (ECs) can undergo an endothelial-mesenchymal transition with tissue fibrosis. Wnt- and Msx2-regulated signals participate in arteriosclerotic fibrosis and calcification. We studied the impact of Wnt7, Msx2, and Dkk1, a Wnt7 antagonist, on endothelial-mesenchymal transition in primary aortic ECs. APPROACH AND RESULTS: Transduction of aortic ECs with vectors expressing Dkk1 suppressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Aortic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arteriosclerosis

Share to Cell Shape

Share to Myofibroblasts

Share to Neovascularization, Physiologic

Share to Ossification, Heterotopic

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 23685555
DOI: 10.1161/ATVBAHA.113.300647
PMCID: PMC3837473

Genes

LDLR
MSX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells.PMID 23685555Read ↗

Endothelial-to-mesenchymal transition primes vascular endothelial cells toward an osteochondrogenic fate.Semantic proximity Read ↗

Endothelial‐to‐mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awrySemantic proximity Read ↗

Endothelial to Mesenchymal Transition in the Cardiogenesis and Cardiovascular DiseasesSemantic proximity Read ↗

Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve diseaseSemantic proximity Read ↗

Endothelial-to-Mesenchymal Transition in Cardiovascular PathophysiologySemantic proximity Read ↗

AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signalingSemantic proximity Read ↗

Sox9 mediates autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosisSemantic proximity Read ↗

Role of endothelial cells in vascular calcificationSemantic proximity Read ↗

COL8A1 regulates endothelial phenotype in inflammatory endothelial-to-mesenchymal transition.Semantic proximity Read ↗

Endothelial-mesenchymal transition in atherosclerosis.Semantic proximity Read ↗

FBLN7 mediates vascular smooth muscle cell phenotype switching and vascular remodeling in hypertension.Semantic proximity Read ↗

Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.