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NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization

29 Aug 2025

Abstract excerpt

Vascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells from a contractile to an osteogenic phenotype. NEXN, a protein highly associated with heart function, has also been implicated as a potential susceptibility factor in the development of coronary artery disease, but its role in the progression of vascular calcification...

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PMID: 40883305
DOI: 10.1038/s41467-025-63462-7

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