Article
Improved use of SNP information to detect the role of genes.
Genetic epidemiology - 1 Sept 2003
Jannot A-S, Essioux L, Reese M G, Clerget-Darpoux F
Abstract excerpt
A topical question in genetic association studies is the optimal use of the information provided by genotyped single-nucleotide polymorphisms (SNPs) in order to detect the role of a candidate gene in a multifactorial disease. We propose a strategy called "combination test" that tests the association between a quantitative trait and all possible phased combinations of various numbers of SNPs. We compare this...
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