Article
Test selection with application to detecting disease association with multiple SNPs.
Human heredity - 1 Jan 2010
Pan Wei, Han Fang, Shen Xiaotong
Abstract excerpt
We consider the motivating problem of testing for association between a phenotype and multiple single nucleotide polymorphisms (SNPs) within a candidate gene or region. Various statistical approaches have been proposed, including those based on either (combining univariate) single-locus analyses or (multivariate) multilocus analyses. However, it is known in theory that there is no single uniformly most powerful...
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