Article
A model to investigate SNPs' interaction in GWAS studies.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2015
Cocchi Enrico, Drago Antonio, Fabbri Chiara, Serretti Alessandro
Abstract excerpt
Genome-wide association studies (GWAS) are able to identify the role of individual SNPs in influencing a phenotype. Nevertheless, such analysis is unable to explain the biological complexity of several diseases. We elaborated an algorithm that starting from genes in molecular pathways implicated in a phenotype is able to identify SNP-SNP interaction's role in association with the phenotype. The algorithm is based...
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