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Article

Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure.

The Journal of cell biology - 2 Jun 2008

Panagopoulou Panagiota, Davos Constantinos H, Milner Derek J, Varela Emily, Cameron Joann, Mann Douglas L, Capetanaki Yassemi

Abstract excerpt

We explored the involvement of the muscle-specific intermediate filament protein desmin in the model of tumor necrosis factor alpha (TNF-alpha)-induced cardiomyopathy. We demonstrate that in mice overexpressing TNF-alpha in the heart (alpha-myosin heavy chain promoter-driven secretable TNF-alpha [MHCsTNF]), desmin is modified, loses its intercalated disk (ID) localization, and forms aggregates that colocalize...

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Identifiers

PMID: 18519735
DOI: 10.1083/jcb.200710049
PMCID: PMC2396798

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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