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Article

MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2002

Li Yun You, Kadokami Toshiaki, Wang Ping, McTiernan Charles F, Feldman Arthur M

Abstract excerpt

Myocardial extracellular matrix remodeling regulated by matrix metalloproteinases (MMPs) is implicated in the progression of heart failure. We hypothesized that MMP inhibition may modulate extracellular matrix remodeling and prevent the progression of heart failure. The effects of the MMP inhibitor BB-94 (also known as batimastat) on MMP expression, collagen expression, collagen deposition, collagen denaturation,...

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Identifiers

PMID: 11834496
DOI: 10.1152/ajpheart.00233.2001

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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