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Article

TACE is required for fetal murine cardiac development and modeling.

Developmental biology - 15 Sept 2003

Shi Wei, Chen Hui, Sun Jianping, Buckley Sue, Zhao Jingsong, Anderson Kathryn D, Williams Roberta G, Warburton David

Abstract excerpt

Tumor necrosis factor-alpha converting enzyme (TACE) is a membrane-anchored, Zn-dependent metalloprotease, which belongs to the ADAM (a disintegrin and metalloprotease) family. TACE functions as a membrane sheddase to release the ectodomain portions of many transmembrane proteins, including the precursors of TNFalpha, TGFalpha, several other cytokines, as well as the receptors for TNFalpha, and neuregulin...

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Identifiers

PMID: 14499647
DOI: 10.1016/s0012-1606(03)00315-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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