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Article

Biochemical and genetic analysis of the vaccinia virus d5 protein: Multimerization-dependent ATPase activity is required to support viral DNA replication.

Journal of virology - 1 Jan 2007

Boyle Kathleen A, Arps Lisa, Traktman Paula

Abstract excerpt

The vaccinia virus-encoded D5 protein is an essential ATPase involved in viral DNA replication. We have expanded the genotypic and phenotypic analysis of six temperature-sensitive (ts) D5 mutants (Cts17, Cts24, Ets69, Dts6389 [also referred to as Dts38], Dts12, and Dts56) and shown that at nonpermissive temperature all of the tsD5 viruses exhibit a dramatic reduction in DNA synthesis and virus production. For...

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Identifiers

PMID: 17093187
DOI: 10.1128/JVI.02217-06
PMCID: PMC1797480

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